Correlation and Accuracy of Labial Minor Salivary Gland Biopsy in the Establishment of Diagnosis in Patients with Suspected Sjögren’s Syndrome

Evangelos G. Kilipirisa, ... Peter Stankof more
a Evangelos G. Kilipiris

PGY4, Oral and Maxillofacial Surgery Residency Program, Comenius University, Faculty of Medicine, Bratislava, Slovak Republic. Corresponding author. Department of Oral and Maxillofacial Surgery, Comenious University, Faculty of Medicine, Moskovska 15, Bratislava 81108, Slovak Republic Tel.: +421944715632, Fax: +421232249724 E-mail address: varonos@live.co.uk (Evangelos G. Kilipiris) Instagram: evangeloskilipiris

b Katarina Machalekova

PhD; Department of Pathology, Slovak Medical University, Faculty of Medicine, and St. Elizabeth Oncologic Institute, Bratislava, Slovak Republic

c Georgia Fountoulaki

Department of Restorative Dentistry, Comenius University, Faculty of Medicine and St. Elizabeth Oncologic Institute, Bratislava, Slovak Republic

d Kareen Andrade

Private Stomatology Clinic, Vina del Mar, Chile

e Nikolaos Mantziaris

Private Dental, Oral Pathology and Otorinolaryngology Practice, Thessaloniki, Greece

f Peter Stanko

PhD, Prof; Chair, Department of Stomatology, Oral and Maxillofacial Surgery, Comenius University, Faculty of Medicine and St. Elizabeth Oncologic Institute, Bratislava, Slovak Republic

September 30, 2018

https://doi.org/10.23999/j.dtomp.2018.3.5

J Diagn Treat Oral Maxillofac Pathol 2018;2:122–31.

Under a Creative Commons license

HOW TO CITE THIS ARTICLE

Kilipiris EG, Machalekova K, Fountoulaki G, Andrade K, Mantziaris N, Stanko P. Correlation and accuracy of labial minor salivary gland biopsy in the establishment of diagnosis in patients with suspected Sjögren’s syndrome. J Diagn Treat Oral Maxillofac Pathol 2018;2(3):122−31.

Abstract

Purpose: The goal of this paper is to find out the correlation, and evaluate the accuracy of labial minor salivary gland biopsy as a diagnostic tool in the multidisciplinary management of patients with Sjögren’s syndrome.

Patients and Methods: Thirty seven patients referred to our outpatient office between January 2016 and December 2017 from a rheumatologist for biopsy examination, as part of the complex diagnostic plan for suspected Sjögren syndrome were included in the current study. Each specimen was examined histomorphometrically by the pathologist to calculate the focus score describing the degree of salivary gland inflammatory infiltration.

Results: From the total number of patients, 25 presented with an established Sjögren syndrome diagnosis by fulfilling the revised American-European criteria. From those 15 had a positive lip biopsy. The rest 10 patients from the total group who were diagnosed with Sjögren syndrome based on the same criteria had a negative lip biopsy.

Conclusion: The labial minor salivary gland biopsy is a valuable diagnostic tool to establish the diagnosis of Sjögren syndrome. However, a positive biopsy result must always be correlated with all the other diagnostic criteria to prove the exact diagnosis.

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