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Vol. 9, Issue 11

Volume 9, Issue 11

Pages 1–15

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Bone Formation in Peripheral Giant Cell Granuloma: A Case Report with a First Clinical, Radiographic, Ultrasonographic, Macroscopic, and Histopathologic Comparison

Valentyn H. Demidova, ... Alla P. Chernetsovaf more
a Valentyn H. Demidov

Doctor-Stomatologist-Surgeon, Center of Maxillofacial Surgery and Dentistry, Kyiv Regional Clinical Hospital, (place of work at moment of material collection), Kyiv, Ukraine.

b Olha S. Cherniak

Doctor of Ultrasound Diagnostics; Head, Department of Ultrasound, Regional Diagnostic Center, Polyclinic, Kyiv Regional Clinical Hospital, Kyiv, Ukraine.

c Ievgen I. Fesenko

Doctor-Stomatologist-Surgeon, PhD, Associate Professor of the Department of Surgical Dentistry and Maxillofacial Surgery, Kyiv Medical University; Center of Maxillofacial Surgery and Dentistry, Kyiv Regional Clinical Hospital, (place of work at moment of material collection), Kyiv, Ukraine. Correspondence: Department of Surgical Dentistry and Maxillofacial Surgery, Kyiv Medical University, Private Higher Educational Establishment, 2 Boryspolska Street, Kyiv 02000, Ukraine. E-mail: y.fesenko@kmu.edu.ua (Ievgen Fesenko). ORCID: https://orcid.org/0000-0002-8901-1632

d Vladyslav Fil

Doctor-Stomatologist-Surgeon, Assistant Professor of the Department of Surgical Dentistry and Maxillofacial Surgery, Kyiv Medical University, Kyiv, Ukraine.

e Valentyna I. Zaritska

Doctor-Pathologist; PhD, Associate Professor, Department of Morphology, Clinical Pathology and Forensic Medicine, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.

f Alla P. Chernetsova

Doctor-Pathologist, Department of Pathomorphology, Kyiv Regional Clinical Hospital, Kyiv, Ukraine.

Published November 30, 2025

J Diagn Treat Oral Maxillofac Pathol 2025; 9: 100312.

DOI: 10.23999/j.dtomp.2025.11.100312    

Under a Creative Commons license (CC BY-NC-SA 4.0)

HOW TO CITE THIS ARTICLE

Demidov VH, Cherniak OS, Fesenko II, Fil V, Zaritska VI, Chernetsova AP. Bone formation in peripheral giant cell granuloma: A case report with a first clinical, radiographic, ultrasonographic, macroscopic, and histopathologic comparison. J Diagn Treat Oral Maxillofac Pathol. 2025 Nov;9(11):100312. https://doi.org/10.23999/j.dtomp.2025.11.100312     

 

SUMMARY

Peripheral giant cell granuloma (PGCG) is one of the benign peripheal reactive lesions of the jaws. Clinically, it is difficult to distinguish from peripheral ossifying fibroma or even metastatic tumor. We report a case of a PGCG in a 64-year-old Caucasian male. Clinically, PGCG presented as a 2.4- × 2-cm saddle-shaped pedunculated lesion of the partially edentulous alveolar ridge of the anterior mandible. The case is unique in that areas of bone formation were noted within the PGCG upon comparison of gray-scale ultrasonography (USG), macroscopic, and histopathological examination. To our knowledge it’s a first ever reported comparison in the medical literature. Indirect ultrasound imaging technique is considered in this article. Prominent intralesional vascularity upon color Doppler USG was proved upon intraoperative step when significant bleeding was noted from soft and bone tissues. Understanding by clinicians of ultrasound patterns in similar cases will facilitate differential diagnosis between alveolar ridge lesions. This paper proves ones again that ultrasound is an essential tool for the oral and maxillofacial surgeons.

KEY WORDS

Peripheral giant cell granuloma, ultrasonography, gray-scale ultrasound, color Doppler ultrasound, bone formation, intralesional vascularity

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